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signs off on Tuesday, after 12 seasons of crime solving, evidence examining, blood, guts and, most importantly, bones.

But at the core of the long-running Fox procedural -- the “heart of the matter,” if you will -- was a partnership between forensic anthropologist Temperance Brennan (Emily Deschanel) and FBI Special Agent Seeley Booth (David Boreanaz).

Everything goes according to plan until Booth realizes that Brennan’s plan to prove her father’s innocence involves implicating herself in the murder instead, something he’s unwilling to go along with, even under oath.

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Plus, the final moments of the episode reveal the telling title of the psychologist’s book about the pair: star Noel Fisher, who plays Teddy Parker, a young corporal who served with Booth in the Army and tragically became his son’s namesake after dying in combat.Parker shows up on the doomed Navy ship that Booth is held captive on, but he can’t be much help because he’s a ghost -- or can he?Booth rushing to Brennan’s side and defense when she becomes a suspect herself -- and finding her mother’s earring at the crime scene -- isn’t even the half of it, though. “The Verdict in the Story” (Season 3, Episode 13)Brennan’s two families come head-to-head during the trial of her father, Max Keenan (Ryan O’Neal), as every other member of the Jeffersonian team is called as expert witnesses for the prosecution.The biggest, most romantic moment of this whole episode might be the introduction of fan favorite Caroline Julian (Patricia Belcher), who will end up becoming perhaps the biggest Booth and Brennan shipper of all. However, the anthropologist plays it cool, insisting she’s fine to her co-workers, FBI psychologist Sweets (John Francis Daley), and even Booth as they all prepare to take the stand in support of evidence that Max killed the deputy director of the FBI.The episode -- and therefore, the season -- ends with Booth assuaging Brennan’s feelings of hurt and guilt at Zach’s betrayal in a sweet personal moment that’s a preview of things to come.

As the team at the Jeffersonian look through Zach’s favorite stuff and Brennan worries that she never gave her former assistant anything tangible, Booth finds the acceptance letter she sent him three years ago and reads it aloud. “The Crack in the Code” (Season 7, Episode 6)The more obvious choice would probably be the episode following this one, “The Prisoner in the Pipe,” when Brennan gives birth to the couple’s daughter, Christine, but watching Booth finally find his family’s home is just too endearing.

Two kids and countless hurdles later, they’re still going strong.

So, as we say goodbye to Booth and Brennan -- and the rest of the beloved “Squint Squad” -- here’s a look back at some of the pair’s very best hours together: 22.

Maybe then we could try to be together.” Booth suggests they each write down a date, before burning the slip of paper to release the wish into the universe. That rule holds true for this season four episode that starts out in the world of Norwegian black metal and ends on a heartbreaker, with Booth and Brennan sharing some of their darkest childhood secrets with Sweets in order to “metaphorically compare scars” with the young FBI shrink, who has a similarly mottled past.

OK -- is for Sweets’ benefit, but it’s also an unmistakable step in the couple’s now-undeniable emotional relationship.

They recover, reconnect and discuss returning to their respective jobs, admitting their undying love for the work that brought them together in the first place.